10/9/2023 0 Comments Define pathological fatigueIn addition, the inadequacy and subjective cognitive impairment commonly reported by patients is not well understood contributing to the limitations regarding efficient treatment alternatives. However, there is still no clear explanation regarding the neurobiological underpinnings of brain fatigue. Recent neuroimaging studies on pathological fatigue in neurological illnesses has been suggested to be linked to dysfunction in brain activity as measured with functional magnetic resonance imaging and functional near-infrared spectroscopy, as well as altered brain connectivity, cerebral blood flow, and glucose metabolism. A dopamine imbalance in the brain has been suggested to cause fatigue, while another theoretical model proposes reduced glutamate handling by astrocytes, more unspecific signaling of larger cell networks, and reduced energy supply to be the culprit. Recent research findings suggest a neurobiological origin for brain fatigue. Pathological fatigue is commonly reported in many neurologic illnesses, including stroke, traumatic brain injury, multiple sclerosis, and Parkinson’s disease. This results in a negative impact on the overall well-being and quality of life. When not resolved within months, long-lasting or chronic pathological fatigue limits the ability to perform normal daily activities including work, education, and social activities. The mental energy varies depending on activities performed, but it never goes back to levels an individual experienced before a neurological insult, and does not recover following a night’s sleep. The endurance of patients is limited and the recovery from exertion can be extremely long. Pathological fatigue is one of the most distressing and long-lasting symptoms following neurological disorders.
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